Web-based portal for comprehensive protein sequence data analysis using advanced deep learning tools

EnzymeX provides (1) trustworthy deep learning tools that predict enzyme commission (EC) numbers, including ECPICK (Han et al., 2024), HIT-EC (Dumontet et al., 2025) and CLEAN (Tianhao et al., 2023), (2) databases for protein sequence analysis tool development, (3) EC number browser.

New features coming soon!

• January 2026 ECPICK, HIT-EC, CLEAN models

Cite as

• Dumontet, L., Han, S.-R., Oh, T.-J., & Kang, M. (2025). HIT-EC: Trustworth prediction of enzyme commission numbers using a hierarchical interpretable transformer. Nature Communication


• Han, S.-R., Park, M., Kosaraju, S., Lee, J., Lee, H., Lee, J. H., Oh, T.-J., & Kang, M. (2024). Evidential deep learning for trustworthy prediction of enzymes commission number. Briefings in Bioinformatics, 25(1), bbad401


• Yu, T., Cui, H., Li, J. C., Luo, Y., Jiang, G., & Zhao, H. (2023). Enzyme function prediction using contrastive learning. Science